ROLE OF TRANSPORTERS IN THE DISTRIBUTION OF PLATINUM-BASED DRUGS
Platinum derivatives used as chemotherapeutic drugs such as cisplatin and oxaliplatin have a potent antitumor activity.However, severe side effects such as nephro-, oto-, and neurotoxicity are associated with their use.Effects and side effects of platinum-based drugs are in part caused by their transporter-mediated uptake in target and non target c